The use of PRP injections has become a prevalent treatment in musculoskeletal conditions within the past few years. PRP injections have been found to be safe and accelerate the soft tissue healing process. PRP is a modern-world treatment approach with worldwide recognition. It has become one of the best methods to support the healing and regenerative process of many different tissues. Platelet Rich Plasma therapy has hit orthopedics by storm, it is the first true biologic treatment option which is safe and easy to use – making it the preferred therapeutic option for physicians and patients. PRP therapy c an be used to treat rotator cuff tears, osteoarthritis of the knee, hamstring injuries, Achilles tendinopathy, lateral epicondylitis, and ulnar collateral ligament tears. PRP in Osteoarthritis: According to many clinical studies, PRP has been observed to increase the regeneration process in the arthritic cartilage due to its high concentration of growth factors.Additionally, PRP stimulates local cell activity and it is low-priced with no side-effects for the patient. Due to the presence of the concentrated growth factors, PRP modulates the phen otypic expression of chondrocytes, improving their recovery . as PDGF stimulates proliferation of chondrocytes and IGF increases the synthesis of proteoglycan – increasing the strength of cartilage . As PRP has many regenerative properties, not only does it stimulate cellular activity, but it can also improve bone and cartilage recovery with the application of biomaterials . PRP in Tendinopathies: PRP treatment in tendinopathies has been studied extensively; and most obtained results have been positive.
The utilization of PRP treatment in tendinopathy procedures have increased the types of expression in collagen genes within tendon cell cultures . As TGF-b plays a major role in differentiating stem cells into chondrocytes, the synthesis of the cartilagino us matrix is improved. PDGF and IGF are both key parts of the recovery process as one may know; Clinical trials have also shown that there were significant improvements in pain felt by patients suffering from chronic elbow tendinosis after only one PRP treatment! Additional clinical trials have shown successful applications of PRP in Achilies.tendon injuries in conjunction with stem cells and other different tendinopathies, including: patellar tendonitis, hamstrings, plantar fasciitis, epicondylitis, plantar fasciitis, biceps brachii tendonitis, athletic pubalgias, and iliopsoas tendonitis The local application of PRP in these issues reported a 75% success ration in patients . PRP in Anterior Cruciate Ligament (ACL) Due to the growing awareness of PRP, therapeutic applications for the treatment method have increased dramatically – specifically in the both soft and bone tissue. Results in many studies have concluded positive results from PRP treatment. Specifically by Sánchez etal., better healing outcomes and less complications were noted after applying PRP to 100 patients with ACL reconstruction .
References  Kossev, P., & Sokolov, T. (2015). Platelet-rich Plasma (PRP) in Orthopedics and Traumatology — Review. Immunopathology and Immunomodulation .doi:10.5772/61326  Sánchez M, Azofra J, Aizpurua B, et al. Use of autologous plasma rich in growth factors in arthroscopic surgery. Cuader Artroscopia. 2003;10:12 – 19.