Platelet-rich plasma, an autologous fractionation of whole blood containing high concentration of growth factors, has been proven to effectively enhance healing and angiogenesis by reparative cell signaling . PRP includes vascular endothelial growth factor (VEGF), platelet-derived growth factor, epithelial growth factor and derived growth factor (TGF- β1) that is secreted by platelet to trigger the healing cascade. In regards to methodology, PRP can be applied surgically (epicadial) into the ischemic areas with a thin needle. The less invasive interventional delivery routes can be transendocardial catheter injection . PRP has emerged as an additional method for repairing cardiac muscle due to its regenerative properties. Recent studies have stated that PRP-derived growth factors inserted into biomaterials can open new horizons in the myocardial infraction treatment .
Resources  Figure 2f from: Irimia R, Gottschling M (2016) Taxonomic revision of Rochefortia Sw. (Ehretiaceae, Boraginales). Biodiversity Data Journal 4: E7720. https://doi.org/10.3897/BDJ.4.e7720. (2015). Role of Platelet-rich Plasma in Ischemic Heart Disease: An Update on the Latest Evidence. doi:10.3897/bdj.4.e7720.figure2f